Deisy turned our method for calculating weighted topological overlap (wTO) networks into an R package and published it in BMC Bioinformatics. The method was developed by Eivind Almaas for describing a transcription factor network in the prefrontal cortex of humans and chimpanzees. It is especially useful, when gene interactions can be positive or negative, such as in regulatory networks. The R package implements this wTO method and allows further for calculating p-values for each link and consensus networks. It thus produces networks with much reduced noise.