In this paper we describe the genome of a German individual for which we independently sequenced both haplotype sequences of each chromosome. We revealed that most genes and their regulatory regions have different sequences on the two chromosomes. This means that for some proteins, a cell can produce two different versions with different functionalities and sometimes in different quantities. Zinc finger proteins are enriched among these proteins, which increases the number of different transcription factors that are active in a cell and might allow for a more complex or fine-tuned gene regulation.
The work was led by Dr. Margret Hoehe at the Max-Planck-Institute for Molecular Genetics in Berlin. You can access the genome via the UCSC genome browser: http://www.molgen.mpg.de/~genetic-variation/MaxPlanckOneUCSC. Here is a link to the paper: http://genome.cshlp.org/content/early/2011/08/02/gr.125047.111.abstract